Alexies Dagnino Subiabre

alexies-dagnino

Investigador principal de Laboratorio de Neurobiología del Stress
Bioquímico, Doctor en en Ciencias Biomédicas

alexies.dagnino@uv.cl

LINEAS DE INVESTIGACIÓN

  • Neurobiología del Stress y la Resliencia.
  • Comportamiento y registros electrofisiológicos in vivo
  • Aprendizaje y memoria

Proyectos vigentes:

  • 2016-2019 (March). “From presbycusis to dementia: a basic and clinical approach”. Anillo de Investigación en Ciencia y Tecnología grant Nº ACT1403. Principal Investigator. Funding amount: $ 450.000.000 Chilean pesos (664.697,00 USD).
  • 2014-2018 (March). “Effects of n-3 fatty acids and endocannabinoids on learning and auditory attention of chronically stressed rats”. FONDECYT Regular Nº 1141276. Principal Investigator. Funding amount: $ 230.504.000 Chilean pesos (340.478,00 USD).
  • 2013-2016. “Regulation of long-term plasticity at inhibitory circuits by acetylcholine: new role of parvalbumin-positive interneurons in the hippocampal function and memory”. FONDECYT Regular Nº 1130614. Co-Investigator. Funding amount: $ 199.997.000 Chilean pesos (295.416,00 USD).

Publicaciones:

  • Moreno-Gómez FN, Véliz G, Rojas M, Martinez C, Olmedo R, Panussis, Dagnino-Subiabre A, Delgado C, Delano PH. 2017.Music training and education slow the deterioration of music perception produced by presbycusis in the elderly. Frontiers in Aging Neuroscience. doi: 10.3389/fnagi.2017.00149. (ISI = 4.3)
  • Pérez MÁ, Peñaloza-Sancho V, Ahumada J, Fuenzalida M, Dagnino-Subiabre A(*). 2017. N-3 Polyunsaturated Fatty Acid Supplementation Restored Impaired Memory and GABAergic Synaptic Efficacy in the Hippocampus of Stressed rats. Nutritional Neuroscience. doi: 10.1080/1028415X.2017.1323609. (ISI = 2.6)
  • Pérez-Valenzuela C, Gárate-Pérez M, Sotomayor-Zárate R, Delano PH, Dagnino-Subiabre A(*). 2016. Reboxetine improves auditory attention and increases norepinephrine levels in the auditory cortex of chronically stressed rats. Frontiers in Neural Circuit. 10:108. (ISI = 3.9)
  • Pérez MA, Peñaloza-Sancho V, Ahumada J, Fuenzalida M, Dagnino-Subiabre A(*). 2016. n-3 polyunsaturated fatty acid supplementation restored impaired memory and GABAergic synaptic efficacy in the rat hippocampus. Prostaglandins, Leukotrienes and Essential Fatty Acids. Under Review. (ISI = 3.2)
  • Moreno-Gómez F, Véliz G, Rojas M, Martínez C, Olmedo R, Panussis F, Dagnino-Subiabre A, Delgado C, Delano PH. 2016.Music training and education slow the deterioration of music perception produced by age-related hearing loss. Frontiers Aging Neuroscience. Under Review. (ISI = 4.3)
  • Negrón-Oyarzo I, Dagnino-Subiabre A, Muñoz P. 2015. Synaptic impairment in layer 1 of the prefrontal cortex induced by repeated stress during adolescence is reversed in adulthood. Frontiers in Cellular Neuroscience. 12;9:442. (ISI = 4.6)
  • Negrón-Oyarzo I, Pérez MA, Terreros G, Muñoz P, Dagnino-Subiabre A(*). 2014. Effects of chronic stress in adolescence on learned fear, anxiety, and synaptic transmission in the rat prelimbic cortex. Behav Brain Res. 259:342-53. (ISI = 3.4)
  • Cruz G, Riquelme R, Espinosa P, Jara P, Dagnino-Subiabre A, Renard GM, Sotomayor-Zárate R. 2014. Neonatal exposure to estradiol valerate increases dopamine content in nigrostriatal pathway during adulthood in the rat. Horm Metab Res. 46(5):322-7. (ISI = 2.2)
  • Pérez MA, Terreros G, Dagnino-Subiabre A(*). 2013. Long-term omega-3 fatty acid supplementation induces anti-stress effects and improves learning in rats. Behav Brain Funct. 9(1):25. (ISI = 2.0)
  • Pérez MÁ, Pérez-Valenzuela C, Rojas-Thomas F, Ahumada J, Fuenzalida M, Dagnino-Subiabre A(*). 2013. Repeated restraint stress impairs auditory attention and GABAergic synaptic efficacy in the rat auditory cortex. Neuroscience. 246C:94-107. (ISI = 3.3).
  • Dagnino-Subiabre A(*). 2013. Effects of chronic stress on the auditory system and fear learning: an evolutionary approach. Reviews in the Neurosciences. 24(2):227-237. (ISI = 3.3).
  • Dagnino-Subiabre A(*), Pérez MA, Terreros G, Cheng MY, House P, Sapolsky MR. 2012. Corticosterone Treatment Impairs Auditory Fear Learning and the Dendritic Morphology of the Rat Inferior Colliculus. Hearing Research. 294(1-2):104-113. (ISI = 3.6)
  • Vega-Gálvez, Dagnino-Subiabre A, Terreros G, López J, Miranda M, Di Scala K. 2011. Mathematical modeling of convective air drying of quinoa-suplemented feed for laboratory rats. Brazilian Archives of Biology and Technology. Vol. 54, Nº 1, pp. 161-171. (ISI = 0.5)
  • Ampuero E, Rubio FJ, Falcon R, Sandoval M, Diaz-Veliz G, Gonzalez RE, Earle N, Dagnino-Subiabre A, Aboitiz F, Orrego F, Wyneken U. 2010. Chronic fluoxetine treatment induces structural plasticity and selective changes in glutamate receptor subunits in the rat cerebral cortex. Neuroscience. 169, 98-108. (ISI = 3.6)
  • Bose M, Muñoz-Llancao P, Roychowdhury S, Nichols JA, Jakkamsetti V, Porter B, Byrapureddy R, Salgado H, Kilgard MP, Aboitiz F, Dagnino-Subiabre A(*), Atzori M*. 2010. Effect of the environment on the dendritic morphology of the rat auditory cortex.Synapse. 64(2):97-110. (ISI = 2.5)
  • Dagnino-Subiabre A(*), Muñoz-Llancao P, Terreros G, Wyneken U, Díaz-Véliz G, Porter B, Kilgard MP, Atzori M, Aboitiz F. 2009. Chronic stress induces dendritic atrophy in the rat medial geniculate nucleus: effects on auditory conditioning. Behavioral Brain Research. 203(1):88-96. (ISI = 3.4)
  • Paris I, Lozano J, Cardenas S, Perez-Pastene C, Saud K, Fuentes P, Caviedes P, Dagnino-Subiabre A, Raisman-Vozari R, Shimahara T, Kostrzewa JP, Chi D, Kostrzewa RM, Caviedes R, Segura-Aguilar J. 2008. The catecholaminergic RCSN-3 cell line: a model to study dopamine metabolism. Neurotoxicity Research. 13(3-4):221-230. (ISI = 3.0)
  • Pancetti F, Olmos C, Dagnino-Subiabre A, Rozas C, Morales B. 2007. Noncholinesterase effects induced by organophosphate pesticides and their relationship to cognitive processes: implication for the action of acylpeptide hydrolase. J Toxicol Environ Health B Crit Rev. 10(8):623-30. (ISI = 3.3)
  • Ampuero E, Dagnino-Subiabre A, Sandoval R, Zepeda-Carreño R, Sandoval S, Viedma A, Aboitiz F, Orrego F, Wyneken U. 2007. Status epilepticus induces region-specific changes in dendritic spines, dendritic length and TrkB protein content of rat brain cortex. Brain Research. 1150:225-38. (ISI = 2.5)
  • Dagnino-Subiabre A(*), Zepeda-Carreño R, Díaz-Véliz G, Mora S, Aboitiz F. 2006. Chronic stress induces upregulation of brain-derived neurotrophic factor (BDNF) mRNA and integrin alpha5 expression in the rat pineal gland. Brain Research. 1086(1):27-34. (ISI = 2.6)
  • Dagnino-Subiabre A(*), Orellana JA, Carmona-Fontaine C, Montiel J, Díaz-Velíz G, Serón-Ferré M, Wyneken U, Concha ML, Aboitiz F. 2006. Chronic stress decreases the expression of sympathetic markers in the pineal gland and increases plasma melatonin concentration in rats. Journal of Neurochemistry. 97(5):1279-87. (ISI = 4.5)
  • Dagnino-Subiabre A(*), Terreros G, Carmona-Fontaine C, Zepeda R, Orellana JA, Díaz-Véliz G, Mora S, Aboitiz F. 2005. Chronic stress impairs acoustic conditioning more than visual conditioning in rats: morphological and behavioural evidence. Neuroscience. 135(4):1067-74. (ISI = 3.6)
  • Hurtado-Guzmán C, Martínez-Alvarado P, Dagnino-Subiabre A, Paris I, Caviedes P, Caviedes R, Cassels BK, Segura-Aguilar J. 2002. Neurotoxicity of some MAO inhibitors in adult rat hypothalamic cell culture. Neurotoxicity Research. 4(2):161-3. (ISI = 3.0)
  • Cárdenas AM, Allen DD, Arriagada C, Olivares A, Bennett LB, Caviedes R, Dagnino- Subiabre A, Mendoza IE, Segura-Aguilar J, Rapoport SI, Caviedes P. 2002. Establishment and characterization of immortalized neuronal cell lines derived from the spinal cord of normal and trisomy 16 fetal mice, an animal model of Down syndrome. J Neurosci Res. 68(1):46-58. (ISI = 3.4)
  • Martinez-Alvarado P, Dagnino-Subiabre A, Paris I, Metodiewa D, Welch CJ, Olea-Azar C, Caviedes P, Caviedes R, Segura-Aguilar J. 2001. Possible role of salsolinol quinone methide in the decrease of RCSN-3 cell survival. Biochem Biophys Res Commun. 283(5):1069-76. (ISI = 2.7)
  • Paris I, Dagnino-Subiabre A, Marcelain K, Bennett LB, Caviedes P, Caviedes R, Azar CO, Segura-Aguilar J. 2001. Copper neurotoxicity is dependent on dopamine-mediated copper uptake and one-electron reduction of aminochrome in a rat substantia nigra neuronal cell line. J Neurochem. 77(2):519-29. (ISI = 4.5)
  • Sjoberg M, Salazar T, Espinosa C, Dagnino A, Avila A, Eggers M, Cassorla F, Carvallo P, Mericq MV. 2001. Study of GH sensitivity in chilean patients with idiopathic short stature. J Clin Endocrinol Metab. 86(9):4375-81. (ISI = 6.3)
  • Dagnino-Subiabre A, Marcelain K, Arriagada C, Paris I, Caviedes P, Caviedes R, Segura-Aguilar J. 2000. Angiotensin receptor II is present in dopaminergic cell line of rat substantia nigra and it is down regulated by aminochrome. Mol Cell Biochem. 212(1-2):131-4. (ISI = 1.8)
  • Arriagada C, Dagnino-Subiabre A, Caviedes P, Armero JM, Caviedes R, Segura-Aguilar J. 2000. Studies of aminochrome toxicity in a mouse derived neuronal cell line: is this toxicity mediated via glutamate transmission? Amino Acids. 18(4):363-73. (ISI = 4.1)
  • Dagnino-Subiabre A, Cassels BK, Baez S, Johansson AS, Mannervik B, Segura-Aguilar J. 2000. Glutathione transferase M2-2 catalyzes conjugation of dopamine and dopa o-quinones. Biochem Biophys Res Commun. 274(1):32-6. (ISI = 2.6)