Líneas de Investigación

Modulación Astroglial de Plasticidad Sináptica y Gliotransmision en enfermedades neurológicas y neurodegenerativas

Proyectos Vigentes

2020-2023 Proyecto FONDECYT Regular: Role of the lateral septum in hedonic regulation of food intake: implications in obesity and food addiction. Financiado por FONDECYT, Proyecto N° 120-0474, Rol: Co-Investigador

2017-2020 Proyecto FONDECYT Regular: GABAergic neurotransmission is critical for controlling the prefrontal cortex spike timing dependent plasticity in schizophrenia. Financiado por FONDECYT, Proyecto N° 117-1006, Rol: Co-Investigador

2016-2019 Proyecto FONDECYT Regular: Neonatal programming: Sex hormones excess disrupts midbrain dopamine function in the adulthood. Financiado por FONDECYT, Proyecto N° 116-0398, Rol: Co-Investigador

2013-2016 Proyecto FONDECYT Regular: The role of astroglial excitability on the modulation of synaptic plasticity during the progression of hippocampal epilepsy. Financiado por FONDECYT, Proyecto N° 113-0491, Rol: Investigador Responsable

Publicaciones

Gliotransmission: A Novel Target for the Development of Antiseizure Drugs. Riquelme J, Wellmann M, Sotomayor-Zárate R, Bonansco C. Neuroscientist. 2020 Jan 24:1073858420901474. doi: 10.1177/1073858420901474.

Priming of GABAergic long-term potentiation by muscarinic receptors. Morales-Weil K, Moreno M, Ahumada J, Arriagada J, Fuentealba P, Bonansco C, Fuenzalida M. Neuroscience. 2020 Jan 6. pii: S0306-4522(19)30888-7. doi: 10.1016/j.neuroscience.2019.12.033.

Programming of Dopaminergic Neurons by Early Exposure to Sex Hormones: Effects on Morphine-Induced Accumbens Dopamine Release, Reward, and Locomotor Behavior in Male and Female Rats. Velásquez VB, Zamorano GA, Martínez-Pinto J, Bonansco C, Jara P, Torres GE, Renard GM, Sotomayor-Zárate R. Front Pharmacol. 2019 Mar 26;10:295. doi: 10.3389/fphar.2019.00295. eCollection 2019.

Astroglial Ca2+-Dependent Hyperexcitability Requires P2Y1 Purinergic Receptors and Pannexin-1 Channel Activation in a Chronic Model of Epilepsy. Wellmann M, Álvarez-Ferradas C, Maturana CJ, Sáez JC, Bonansco C. Front Cell Neurosci. 2018 Nov 23;12:446. doi: 10.3389/fncel.2018.00446. eCollection 2018.

Neonatal exposure to oestradiol increases dopaminergic transmission in nucleus accumbens and morphine-induced conditioned place preference in adult female rats. Bonansco C, Martínez-Pinto J, Silva RA, Velásquez VB, Martorell A, Selva MV, Espinosa P, Moya PR, Cruz G, Andrés ME, Sotomayor-Zárate R. J Neuroendocrinol. 2018 Jul;30(7):e12574. doi: 10.1111/jne.12574.

SVCT2 Expression and Function in Reactive Astrocytes Is a Common Event in Different Brain Pathologies. Salazar K, Martínez F, Pérez-Martín M, Cifuentes M, Trigueros L, Ferrada L, Espinoza F, Saldivia N, Bertinat R, Forman K, Oviedo MJ, López-Gambero AJ, Bonansco C, Bongarzone ER, Nualart F. Mol Neurobiol. 2018 Jul;55(7):5439-5452. doi: 10.1007/s12035-017-0762-5. Epub 2017 Sep 23.

Plasticity of Hippocampal Excitatory-Inhibitory Balance: Missing the Synaptic Control in the Epileptic Brain. Bonansco C, Fuenzalida M. Neural Plast. 2016;2016:8607038. doi: 10.1155/2016/8607038. Epub 2016 Feb 24. Review.

Enhanced astroglial Ca2+ signaling increases excitatory synaptic strength in the epileptic brain. Álvarez-Ferradas C, Morales JC, Wellmann M, Nualart F, Roncagliolo M, Fuenzalida M, Bonansco C. Glia. 2015 Sep;63(9):1507-21. doi: 10.1002/glia.22817. Epub 2015 May 15.