Christian Bonansco Herrera

christian-bonansco

Investigador principal de laboratorio de Neurofisiología Sináptica y Astroglial
christian.bonansco@uv.cl

Líneas de investigación:

  • Modulación Astroglial de Plasticidad Sináptica y Gliotransmision en enfermedades neurológicas y neurodegenerativas

Proyectos vigentes:

  • FONDECYT 1130491: THE ROLE OF ASTROGLIAL EXCITABILITY ON THE MODULATION OF SYNAPTIC PLASTICITY DURING THE PROGRESSION OF HIPPOCAMPAL EPILEPSY (Investigador Principal)
  • FONDECYT 1130614: REGULATION OF LONG-TERM PLASTICITY AT INHIBITORY CIRCUITS BY ACETYLCHOLINE: NEW ROLE OF PARVALBUMIN-POSITIVE INTERNEURONS IN THE HIPPOCAMPAL FUNCTION AND MEMORY (Co-investigador)

Publicaciones:

  • Carla Álvarez-Ferradas, Juan Carlos Morales, Mario Wellmann, Francisco Nualart, Manuel Roncagliolo, Marco Fuenzalida and Christian Bonansco Enhanced astroglial Ca2+ signaling increases excitatory synaptic strength at the epileptic brain. Glia. Accepted 2014.
  • Juan Carlos Morales, Mario Wellmann, Carla Alvarez-Ferradas, Marco Fuenzalida, Manuel Roncagliolo, Francisco Javier Nualart and Christian Bonansco. A new rapid kindling variant for induction of cortical epileptogenesis in freely moving rats. Frontiers in Cellular Neuroscience, July 2014, Vol 8, 2000 (IF: 4.5).
  • Bonansco C, Couve A, Perea G, Roncagliolo M, and Fuenzalida M‡. Glutamate released spontaneously from astrocytes set the threshold on synaptic plasticity. European Journal of Neuroscience 33: 1483-1492, 2011. (IF: 3.6)
  • Loreto Cuitino, Juan Godoy, Christian Bonansco, Andres couve, Marco Fuenzalida, and Nibaldo Inestrosa “Wnt-5a Modulates Recycling of Functional GABAA Receptor on Hippocampal Neurons”. J Neuroscience 2010 Jun 23;30(25):8411-20 (IF: 7.27)
  • Waldo Cerpa, Ginny Farías, Marco Fuenzalida, Christian Bonansco and Nibaldo C. Inestrosa. Wnt-5a occludes Ab oligomer-induced depression of glutamatergic transmission in hippocampal neurons. Mol Neurodegener. Jan 18;5:3. 2010 (IF: 5.3)
  • Fuenzalida M, Aliaga E, Olivares V, Roncagliolo M, Bonansco C. Developmental increase of asynchronic glutamate release from hippocampal synapses in mutant taiep rat. Synapse. Jun;63(6):502-9. 2009 (IF: 2.9)
  • Christian Bonansco, Marco Fuenzalida, Eduardo Couve Esteban Aliaga and Manuel Roncagliolo. The Taiep Rat: A Neurological Mutant as a Model to Understand the Role of Glial Cells in Synaptic Transmission. Austral – Asian Journal of Cancer ISSN-0972-2556, Vol. 8, No. 2, April 2009
  • Bonansco C, Fuenzalida M, Olivares V, Molina C, Roncagliolo M. Asynchronic transmission in the CA3-CA1 hippocampal synapses in the neurological mutant taiep rat. J Neurosci Res. 2007 Jan;85(1):223-9.
  • Fuenzalida M, Roncagliolo P, Bonansco C, Roncagliolo M. Immature developmental pattern of the monosynaptic reflex in isolated spinal cord of glial mutant taiep rats. Brain Res Dev Brain Res. 2004. Nov 25;153(2):197-202.
  • Bonansco C, Fuenzalida M, Roncagliolo M. Altered synaptic and electrical properties of lumbar motoneurons in the neurological glial mutant taiep rat. Exp Brain Res. 2004 May;156(1):104-10.