Líneas de Investigación

  • Mecanismos celulares y moleculares de la plasticidad de sinapsis GABAérgicas
  • Neuromodulación de la transmisión GABAérgica
  • Bases sináptica de enfermedades psiquiátricas: Esquizofrenia.

Proyectos Vigentes

2017-2020 Proyecto FONDECYT Regular: GABAergic neurotransmission is critical for controlling the prefrontal cortex spike timing dependent plasticity in schizophrenia. Financiado por FONDECYT, Proyecto N° 117-1006, Rol: Investigador Responsable

2015-2017 Proyecto Núcleo Milenio: Núcleo milenio biología de enfermedades neuropsiquiátricas NU-MIND. Rol: Investigador Asociado

2013-2016 Proyecto FONDECYT Regular: Regulation of long-term plasticity at inhibitory circuits by acetylcholine: new role of parvalbumin-positive interneurons in the hippocampal function and memory. Financiado por FONDECYT, Proyecto N° 113-0614, Rol: Investigador Responsable

2013-2016 Proyecto FONDECYT Regular: The role of astroglial excitability on the modulation of synaptic plasticity during the progression of hippocampal epilepsy. Financiado por FONDECYT, Proyecto N° 113-0491, Rol: Co-Investigador

Publicaciones

Priming of GABAergic long-term potentiation by muscarinic receptors. Morales-Weil K, Moreno M, Ahumada J, Arriagada J, Fuentealba P, Bonansco C, Fuenzalida M. Neuroscience. 2020 Jan 6. pii: S0306-4522(19)30888-7. doi: 10.1016/j.neuroscience.2019.12.033.

The p75NTR neurotrophin receptor is required to organize the mature neuromuscular synapse by regulating synaptic vesicle availability. Pérez V, Bermedo-Garcia F, Zelada D, Court FA, Pérez MÁ, Fuenzalida M, Ábrigo J, Cabello-Verrugio C, Moya-Alvarado G, Tapia JC, Valenzuela V, Hetz C, Bronfman FC, Henríquez JP. Acta Neuropathol Commun. 2019 Sep 12;7(1):147. doi: 10.1186/s40478-019-0802-7.

Ketamine-Treatment During Late Adolescence Impairs Inhibitory Synaptic Transmission in the Prefrontal Cortex and Working Memory in Adult Rats. Pérez MÁ, Morales C, Santander O, García F, Gómez I, Peñaloza-Sancho V, Fuentealba P, Dagnino-Subiabre A, Moya PR, Fuenzalida M. Front Cell Neurosci. 2019 Aug 20;13:372. doi: 10.3389/fncel.2019.00372. eCollection 2019.

Coordinated prefrontal-hippocampal activity and navigation strategy-related prefrontal firing during spatial memory formation. Negrón-Oyarzo I, Espinosa N, Aguilar-Rivera M, Fuenzalida M, Aboitiz F, Fuentealba P. Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):7123-7128. doi: 10.1073/pnas.1720117115. Epub 2018 Jun 18.

Epigenetic editing of the Dlg4/PSD95 gene improves cognition in aged and Alzheimer’s disease mice. Bustos FJ, Ampuero E, Jury N, Aguilar R, Falahi F, Toledo J, Ahumada J, Lata J, Cubillos P, Henríquez B, Guerra MV, Stehberg J, Neve RL, Inestrosa NC, Wyneken U, Fuenzalida M, Härtel S, Sena-Esteves M, Varela-Nallar L, Rots MG, Montecino M, van Zundert B. Brain. 2017 Dec 1;140(12):3252-3268. doi: 10.1093/brain/awx272.

n-3 Polyunsaturated fatty acid supplementation restored impaired memory and GABAergic synaptic efficacy in the hippocampus of stressed rats. Pérez MÁ, Peñaloza-Sancho V, Ahumada J, Fuenzalida M, Dagnino-Subiabre A. Nutr Neurosci. 2018 Oct;21(8):556-569. doi: 10.1080/1028415X.2017.1323609. Epub 2017 May 8.

Activity-dependent switch of GABAergic inhibition into glutamatergic excitation in astrocyte-neuron networks. Perea G, Gómez R, Mederos S, Covelo A, Ballesteros JJ, Schlosser L, Hernández-Vivanco A, Martín-Fernández M, Quintana R, Rayan A, Díez A, Fuenzalida M, Agarwal A, Bergles DE, Bettler B, Manahan-Vaughan D, Martín ED, Kirchhoff F, Araque A. Elife. 2016 Dec 24;5. pii: e20362. doi: 10.7554/eLife.20362.

Plasticity of Hippocampal Excitatory-Inhibitory Balance: Missing the Synaptic Control in the Epileptic Brain. Bonansco C, Fuenzalida M. Neural Plast. 2016;2016:8607038. doi: 10.1155/2016/8607038. Epub 2016 Feb 24. Review.

Role of Nicotinic and Muscarinic Receptors on Synaptic Plasticity and Neurological Diseases. Fuenzalida M, Pérez MÁ, Arias HR. Curr Pharm Des. 2016;22(14):2004-14. Review.

Wnt signaling pathway improves central inhibitory synaptic transmission in a mouse model of Duchenne muscular dystrophy. Fuenzalida M, Espinoza C, Pérez MÁ, Tapia-Rojas C, Cuitino L, Brandan E, Inestrosa NC. Neurobiol Dis. 2016 Feb;86:109-20. doi: 10.1016/j.nbd.2015.11.018. Epub 2015 Dec 2.

Enhanced astroglial Ca2+ signaling increases excitatory synaptic strength in the epileptic brain. Álvarez-Ferradas C, Morales JC, Wellmann M, Nualart F, Roncagliolo M, Fuenzalida M, Bonansco C. Glia. 2015 Sep;63(9):1507-21. doi: 10.1002/glia.22817. Epub 2015 May 15.

WASP-1, a canonical Wnt signaling potentiator, rescues hippocampal synaptic impairments induced by Aβ oligomers. Vargas JY, Ahumada J, Arrázola MS, Fuenzalida M, Inestrosa NC. Exp Neurol. 2015 Feb;264:14-25. doi: 10.1016/j.expneurol.2014.11.005. Epub 2014 Nov 20.