Marco Fuenzalida Núñez

marco-fuenzalida

Investigador principal de laboratorio de Plasticidad Neuronal
marco.fuenzalida@uv.cl
www.numind.cl

Líneas de investigación:

  • Mecanismos celulares y moleculares de la plasticidad de sinapsis GABAérgicas
  • Neuromodulación de la transmisión GABAérgica
  • Bases sináptica de enfermedades psiquiátricas: Esquizofrenia.

Proyectos vigentes:

  • 2015-2017: Investigador Principal, NUCLEO MILENIO BIOLOGIA DE ENFERMEDADES NEUROPSIQUIATRICAS NU-MIND (2015-2017)
  • 2013-2016: Investigador Principal, Fondecyt 1130614. REGULATION OF LONG-TERM PLASTICITY AT INHIBITORY CIRCUITS BY ACETYLCHOLINE: NEW ROLE OF PARVALBUMIN-POSITIVE INTERNEURONS IN THE HIPPOCAMPAL FUNCTION AND MEMORY.
  • 2013-2016: Co-Investigador, Fondecyt n° 1130491. “THE ROLE OF ASTROGLIAL EXCITABILITY ON THE MODULATION OF SYNAPTIC PLASTICITY DURING THE PROGRESSION OF HIPPOCAMPAL EPILEPSY”.

Publicaciones:

  • Jessica Vargas, Juan Ahumada, Macarena Arrázola, Marco Fuenzalida and Nibaldo Inestrosa. WASP-1, a canonical Wnt signaling potentiator, rescues hippocampal synaptic impairments induced by Aβ oligomers. Experimental Neurology. In press 2014.
  • Carla Álvarez-Ferradas, Juan Carlos Morales, Mario Wellmann, Francisco Nualart, Manuel Roncagliolo, Marco Fuenzalida and Christian Bonansco Enhanced astroglial Ca2+ signaling increases excitatory synaptic strength at the epileptic brain. Glia. Accepted 2014.
  • Juan Carlos Morales, Mario Wellmann, Carla Alvarez-Ferradas, Marco Fuenzalida, Manuel Roncagliolo, Francisco Javier Nualart and Christian Bonansco. A new rapid kindling variant for induction of cortical epileptogenesis in freely moving rats. Frontiers in Cellular Neuroscience, July 2014, Vol 8, 2000 (IF: 4.5).
  • Alvaro O. Ardiles, Carolina Flores-Muñoz, Gabriela Toro-Ayala, Ana M. Cárdenas, Adrian G. Palacios1, Pablo Muñoz, Marco Fuenzalida, Juan C. Sáez and Agustín D. Martínez. Pannexin 1 regulates bidirectional hippocampal plasticity in adult mice. Frontiers in Cellular Neuroscience. Junio 2014 (IF: 4.5).
  • Jessica Vargas, Marco Fuenzalida and Nibaldo Inestrosa. “In vivo activation of Wnt signaling pathway enhances cognitive function of adult mice and reverses cognitive deficits in an Alzheimer’s diseases model. 2014 Feb 5; 34(6):2191-2202. Journal of Neuroscience (IF: 7.27).
  • Juan Ahumada, David Fernández de Sevilla, Alejandro Couve, Washington Buño and Marco Fuenzalida‡. Long-term depression of inhibitory synapses induced by spike- timing dependent plasticity requires co-activation of endocannabinoids and acetylcholine receptors. Hippocampus 2013 Dec; 23(12):1439-52. (IF: 5.492).
  • Miguel Ángel Pérez, Catherine Pérez-Valenzuela, Felipe Rojas-Thomas, Juan Ahumada, Marco Fuenzalida and Alexies Dagnino-Subiabre. Repeated Restraint Stress Impairs Auditory Attention and GABAergic Synaptic Efficacy in the Rat Auditory Cortex. Neuroscience. 2013 Aug 29;246:94-107. doi: 10.1016/j.neuroscience.2013.04.044. (IF: 3.38)
  • Inestrosa NC, Montecinos-Oliva C, Fuenzalida M. Wnt signaling: role in Alzheimer disease and schizophrenia. J Neuroimmune Pharmacol. 2012 Dec;7(4):788-807. doi: 10.1007/s11481-012-9417-5. Epub 2012 Nov 18. (IF: 4.57).
  • Bonansco C, Couve A, Perea G, Roncagliolo M, and Fuenzalida M‡. Glutamate released spontaneously from astrocytes set the threshold on synaptic plasticity. European Journal of Neuroscience 33: 1483-1492, 2011. (IF: 3.6)
  • Loreto Cuitino, Juan Godoy, Christian Bonansco, Andres couve, Marco Fuenzalida, and Nibaldo Inestrosa “Wnt-5a Modulates Recycling of Functional GABAA Receptor on Hippocampal Neurons”. J Neuroscience 2010 Jun 23;30(25):8411-20 (IF: 7.27)
  • Fuenzalida M, Fernández de Sevilla D, Alejandro Couve and Buño W. Role of AMPA –NMDA receptors and back-propagating action potential in spike-timing dependent plasticity. J Neurophysiology, Jan 103(1):47-54, 2010. (IF: 3.3)
  • Waldo Cerpa, Ginny Farías, Marco Fuenzalida, Christian Bonansco and Nibaldo C. Inestrosa. Wnt-5a occludes Ab oligomer-induced depression of glutamatergic transmission in hippocampal neurons. Mol Neurodegener. Jan 18;5:3. 2010 (IF: 5.3)
  • Fuenzalida M, Aliaga E, Olivares V, Roncagliolo M, Bonansco C. Developmental increase of asynchronic glutamate release from hippocampal synapses in mutant taiep rat. Synapse. Jun;63(6):502-9. 2009 (IF: 2.9)
  • Christian Bonansco, Marco Fuenzalida, Eduardo Couve Esteban Aliaga and Manuel Roncagliolo. The Taiep Rat: A Neurological Mutant as a Model to Understand the Role of Glial Cells in Synaptic Transmission. Austral – Asian Journal of Cancer ISSN-0972-2556, Vol. 8, No. 2, April 2009
  • Fuenzalida M, Fernández de Sevilla D and Buño W. The temporal window for spike timing dependent plasticity is regulated by the slow calcium-dependent alter hyperpolarization. Journal Neuroscience 27:11940-8, 2007. (IF: 7.27)
  • *Fernandez de Sevilla D, *Fuenzalida M, Porto Pazos AB, Buno W. Selective shunting of NMDA EPSP component by the Slow After Hyperpolarization in rat CA1 pyramidal neurons. J Neurophysiol. 97:3242-3255, 2007. * D. Fernández de Sevilla and M. Fuenzalida contributed equally to this work. (IF: 3.3)
  • Bonansco C, Fuenzalida M, Olivares V, Molina C, Roncagliolo M. Asynchronic transmission in the CA3-CA1 hippocampal synapses in the neurological mutant taiep rat. J Neurosci Res. 2007 Jan;85(1):223-9.
  • Fuenzalida M, Roncagliolo P, Bonansco C, Roncagliolo M. Immature developmental pattern of the monosynaptic reflex in isolated spinal cord of glial mutant taiep rats. Brain Res Dev Brain Res. 2004. Nov 25;153(2):197-202.
  • Le Ray D, Fernandez De Sevilla D, Belen Porto A, Fuenzalida M, Buno W. Heterosynaptic metaplastic regulation of synaptic efficacy in CA1 pyramidal neurons of rat hippocampus. Hippocampus. 2004;14(8):1011-25.
  • Bonansco C, Fuenzalida M, Roncagliolo M. Altered synaptic and electrical properties of lumbar motoneurons in the neurological glial mutant taiep rat. Exp Brain Res. 2004 May;156(1):104-10.