Líneas de Investigación

Neurobiología: Mecanismos neuroquímicos, celulares y moleculares asociados al sistema dopaminérgico.

Neurofarmacología: Caracterización neuroquímica y conductual de derivados anfetamínicos.

Neuroendocrinología: Programación neonatal con hormonas sexuales y sus efectos sobre el Sistema Mesocorticolímbico. Diferencias Sexuales

Neuroanatomía funcional: Caracterización de la regulación Neuroquímica de la liberación de dopamina en el Septum Lateral de rata.

Proyectos Vigentes

2020-2023 Proyecto FONDECYT Regular: Role of the lateral septum in hedonic regulation of food intake: implications in obesity and food addiction. Financiado por FONDECYT, Proyecto N° 120-0474, Rol: Investigador Responsable

2020-2023 Proyecto FONDECYT Regular: Role of multisystem activation of sympathetic nerves induced by leptin on the pathogenesis of nonalcoholic fatty liver disease and polycystic ovary in offspring of obese mothers. Financiado por FONDECYT, Proyecto N° 120-1816 Rol: Co-Investigador

2019-2021 Proyecto FONDECYT Regular: Effects of early-life intestinal dysbiosis on the rats mesocorticolimbic circuit. Financiado por FONDECYT, Proyecto N° 119-0729, Rol: Co-Investigador

2016-2019 Proyecto FONDECYT Regular: Neonatal programming: Sex hormones excess disrupts midbrain dopamine function in the adulthood. Financiado por FONDECYT, Proyecto N° 116-0398, Rol: Investigador Responsable

2017-2018 Proyecto Concurso Nacional de Atracción de Capital Humano Avanzado del Extranjero, Modalidad Estadías Cortas – MEC- 2016: Mecanismos neurobiológicos asociados con el uso de anfetaminas: Papel de las hormonas sexuales. Financiado por CONICYT, Proyecto PAI80160020, Rol: Investigador Responsable. Investigador Extranjero: Gonzalo E. Torres University of Florida Estados Unidos de América

2014-2016 Proyecto FONDECYT Regular: Generation and functional characterization of mice with altered expression of EAAT3: A model for obsessive-compulsive disorder. Financiado por FONDECYT, Proyecto N° 114-1272, Rol: Co-Investigador

2012-2015 Proyecto FONDECYT de Iniciación en Investigación: Effect of neonatal exposure to sex hormones on dopamine neurotransmission of the adult rat. Implications in the development of addictive behavior. Financiado por FONDECYT, Proyecto N° 111-21205, Rol: Investigador Responsable

Publicaciones

Involvement of NO in Antinociception of NSAIDS in Murine Formalin Hind Paw Assay. Noriega V, Miranda HF, Prieto JC, Sotomayor-Zárate R, Sierralta F. Drug Res (Stuttg). 2020 Jan 30. doi: 10.1055/a-1095-5418.

Gliotransmission: A Novel Target for the Development of Antiseizure Drugs. Riquelme J, Wellmann M, Sotomayor-Zárate R, Bonansco C. Neuroscientist. 2020 Jan 24:1073858420901474. doi: 10.1177/1073858420901474.

UFR2709, a Nicotinic Acetylcholine Receptor Antagonist, Decreases Ethanol Intake in Alcohol-Preferring Rats. Quiroz G, Sotomayor-Zárate R, González-Gutierrez JP, Vizcarra F, Moraga F, Bermudez I, Reyes-Parada M, Quintanilla ME, Lagos D, Rivera-Meza M, Iturriaga-Vásquez P. Front Pharmacol. 2019 Dec 3;10:1429. doi: 10.3389/fphar.2019.01429. eCollection 2019.

Vasopressin in the lateral septum decreases conditioned place preference to amphetamine and nucleus accumbens dopamine release. Gárate-Pérez MF, Méndez A, Bahamondes C, Sanhueza C, Guzmán F, Reyes-Parada M, Sotomayor-Zárate R, Renard GM. Addict Biol. 2019 Nov 6:e12851. doi: 10.1111/adb.12851.

Pre- and postnatal alcohol exposure delays, in female but not in male rats, the extinction of an auditory fear conditioned memory and increases alcohol consumption. Plaza W, Gaschino F, Gutierrez C, Santibañez N, Estay-Olmos C, Sotomayor-Zárate R, De la Fuente-Ortega E, Pautassi RM, Haeger PA. Dev Psychobiol. 2019 Sep 28. doi: 10.1002/dev.21925.

Do your gut microbes affect your brain dopamine? González-Arancibia C, Urrutia-Piñones J, Illanes-González J, Martinez-Pinto J, Sotomayor-Zárate R, Julio-Pieper M, Bravo JA. Psychopharmacology (Berl). 2019 May;236(5):1611-1622. doi: 10.1007/s00213-019-05265-5. Epub 2019 May 17. Review.

Programming of Dopaminergic Neurons by Early Exposure to Sex Hormones: Effects on Morphine-Induced Accumbens Dopamine Release, Reward, and Locomotor Behavior in Male and Female Rats. Velásquez VB, Zamorano GA, Martínez-Pinto J, Bonansco C, Jara P, Torres GE, Renard GM, Sotomayor-Zárate R. Front Pharmacol. 2019 Mar 26;10:295.

G protein βγ subunits play a critical role in the actions of amphetamine. Mauna JC, Harris SS, Pino JA, Edwards CM, DeChellis-Marks MR, Bassi CD, Garcia-Olivares J, Amara SG, Guajardo FG, Sotomayor-Zarate R, Terminel M, Castañeda E, Vergara M, Baust T, Thiels E, Torres GE. Transl Psychiatry. 2019 Feb 11;9(1):81. doi: 10.1038/s41398-019-0387-8.

Behavioral and synaptic alterations relevant to obsessive-compulsive disorder in mice with increased EAAT3 expression. Delgado-Acevedo C, Estay SF, Radke AK, Sengupta A, Escobar AP, Henríquez-Belmar F, Reyes CA, Haro-Acuña V, Utreras E, Sotomayor-Zárate R, Cho A, Wendland JR, Kulkarni AB, Holmes A, Murphy DL, Chávez AE, Moya PR. Neuropsychopharmacology. 2019 May;44(6):1163-1173. doi: 10.1038/s41386-018-0302-7.

Prenatal metformin treatment improves ovarian function in offspring of obese rats. Álvarez D, Ceballo K, Olguín S, Martinez-Pinto J, Maliqueo M, Fernandois D, Sotomayor-Zárate R, Cruz G. J Endocrinol. 2018 Dec 1;239(3):325-338. doi: 10.1530/JOE-18-0352.

Proteostasis and Mitochondrial Role on Psychiatric and Neurodegenerative Disorders: Current Perspectives. Olivero P, Lozano C, Sotomayor-Zárate R, Meza-Concha N, Arancibia M, Córdova C, González-Arriagada W, Ramírez-Barrantes R, Marchant I. Neural Plast. 2018 Jun 27;2018:6798712. doi: 10.1155/2018/6798712. eCollection 2018. Review.

Developmental programming of the female neuroendocrine system by steroids. Abruzzese GA, Crisosto N, De Grava Kempinas W, Sotomayor-Zárate R. J Neuroendocrinol. 2018 Oct;30(10):e12632. doi: 10.1111/jne.12632. Epub 2018 Aug 7. Review.

Erysodine, a competitive antagonist at neuronal nicotinic acetylcholine receptors, decreases ethanol consumption in alcohol-preferring UChB rats. Quiroz G, Guerra-Díaz N, Iturriaga-Vásquez P, Rivera-Meza M, Quintanilla ME, Sotomayor-Zárate R. Behav Brain Res. 2018 Sep 3;349:169-176. doi: 10.1016/j.bbr.2018.04.038. Epub 2018 Apr 25.

Neonatal exposure to oestradiol increases dopaminergic transmission in nucleus accumbens and morphine-induced conditioned place preference in adult female rats. Bonansco C, Martínez-Pinto J, Silva RA, Velásquez VB, Martorell A, Selva MV, Espinosa P, Moya PR, Cruz G, Andrés ME, Sotomayor-Zárate R. J Neuroendocrinol. 2018 Jul;30(7):e12574. doi: 10.1111/jne.12574.

Neonatal programming with testosterone propionate reduces dopamine transporter expression in nucleus accumbens and methylphenidate-induced locomotor activity in adult female rats. Dib T, Martínez-Pinto J, Reyes-Parada M, Torres GE, Sotomayor-Zárate R. Behav Brain Res. 2018 Jul 2;346:80-85. doi: 10.1016/j.bbr.2017.12.001. Epub 2017 Dec 6.

Neurochemical and behavioral characterization of neuronal glutamate transporter EAAT3 heterozygous mice. González LF, Henríquez-Belmar F, Delgado-Acevedo C, Cisternas-Olmedo M, Arriagada G, Sotomayor-Zárate R, Murphy DL, Moya PR. Biol Res. 2017 Sep 19;50(1):29. doi: 10.1186/s40659-017-0138-3.

Anxiogenic effects of a Lactobacillus, inulin and the synbiotic on healthy juvenile rats. Barrera-Bugueño C, Realini O, Escobar-Luna J, Sotomayor-Zárate R, Gotteland M, Julio-Pieper M, Bravo JA. Neuroscience. 2017 Sep 17;359:18-29. doi: 10.1016/j.neuroscience.2017.06.064. Epub 2017 Jul 8.

Amphetamine treatment affects the extra-hypothalamic vasopressinergic system in a sex- and nucleus-dependent manner. Ahumada C, Bahamondes C, Cerda CA, Silva RA, Cruz G, Moya PR, Sotomayor-Zárate R, Renard GM. J Neuroendocrinol. 2017 Apr;29(4). doi: 10.1111/jne.12465.

Reboxetine Improves Auditory Attention and Increases Norepinephrine Levels in the Auditory Cortex of Chronically Stressed Rats. Pérez-Valenzuela C, Gárate-Pérez MF, Sotomayor-Zárate R, Delano PH, Dagnino-Subiabre A. Front Neural Circuits. 2016 Dec 27;10:108. doi: 10.3389/fncir.2016.00108. eCollection 2016.

The activation of metabotropic glutamate 5 receptors in the rat ventral tegmental area increases dopamine extracellular levels. Ferrada C, Sotomayor-Zárate R, Abarca J, Gysling K. Neuroreport. 2017 Jan 1;28(1):28-34.

Programming of Dopaminergic Neurons by Neonatal Sex Hormone Exposure: Effects on Dopamine Content and Tyrosine Hydroxylase Expression in Adult Male Rats. Espinosa P, Silva RA, Sanguinetti NK, Venegas FC, Riquelme R, González LF, Cruz G, Renard GM, Moya PR, Sotomayor-Zárate R. Neural Plast. 2016;2016:4569785. doi: 10.1155/2016/4569785. Epub 2016 Jan 10.

Increase in endogenous estradiol in the progeny of obese rats is associated with precocious puberty and altered follicular development in adulthood. Ambrosetti V, Guerra M, Ramírez LA, Reyes A, Álvarez D, Olguín S, González-Mañan D, Fernandois D, Sotomayor-Zárate R, Cruz G. Endocrine. 2016 Jul;53(1):258-70. doi: 10.1007/s12020-016-0858-0. Epub 2016 Jan 14.

Pharmacological models and approaches for pathophysiological conditions associated with hypoxia and oxidative stress. Farías JG, Herrera EA, Carrasco-Pozo C, Sotomayor-Zárate R, Cruz G, Morales P, Castillo RL. Pharmacol Ther. 2016 Feb;158:1-23. doi: 10.1016/j.pharmthera.2015.11.006. Epub 2015 Nov 23. Review.

Exposure to repeated immobilization stress inhibits cocaine-induced increase in dopamine extracellular levels in the rat ventral tegmental area. Sotomayor-Zárate R, Abarca J, Araya KA, Renard GM, Andrés ME, Gysling K. Pharmacol Res. 2015 Nov;101:116-23. doi: 10.1016/j.phrs.2015.08.015. Epub 2015 Aug 28.

Introductory letter: Address from the President of the Chilean Society of Pharmacology. Sotomayor-Zárate R. Pharmacol Res. 2015 Nov;101:1. doi: 10.1016/j.phrs.2015.07.030. Epub 2015 Jul 31. No abstract available.

“How and when Chilean Pharmacology started to be experimental and became a science”. Bustos G, Renard GM, Noriega V, Sotomayor-Zárate R. Pharmacol Res. 2015 Nov;101:2-8. doi: 10.1016/j.phrs.2015.07.007. Epub 2015 Jul 17.