Líneas de Investigación
Neuroendocrinología y Metabolismo. Nuevos mecanismos de control de la ingesta de alimentos y la homeostasis energética.
Programación del Desarrollo. Efectos de dietas hipercalóricas durante la gestación sobre la función reproductiva y metabólica de la descendencia.
Farmacología Endocrina. Estudio de los efectos de fármacos o fitofármacos en modelos animales de obesidad en el ciclo vital.
Proyectos Vigentes
2020-2023 Proyecto FONDECYT Regular: Role of multisystem activation of sympathetic nerves induced by leptin on the pathogenesis of nonalcoholic fatty liver disease and polycystic ovary in offspring of obese mothers. Financiado por FONDECYT, Proyecto N° 120-1816 Rol: Investigador Responsable
2020-2023 Proyecto FONDECYT Regular: Role of the lateral septum in hedonic regulation of food intake: implications in obesity and food addiction. Financiado por FONDECYT, Proyecto N° 120-0474, Rol: Co-Investigador
2018-2020 Proyecto FONDECYT Regular: Obesity and alterations of colon submucosal neurons. Financiado por FONDECYT, Proyecto N° 118-1019, Rol: Co-Investigador
Publicaciones
Modafinil Administration to Preadolescent Rat Impairs Non-Selective Attention, Frontal Cortex D2 Expression and Mesolimbic GABA Levels. Int J Mol Sci. 2022 Jun 13;23(12):6602. doi: 10.3390/ijms23126602.
NLRP3 Inflammasome: Potential Role in Obesity Related Low-Grade Inflammation and Insulin Resistance in Skeletal Muscle. Int J Mol Sci. 2021 Mar 23;22(6):3254. doi: 10.3390/ijms22063254.
High extracellular ATP levels released through pannexin-1 channels mediate inflammation and insulin resistance in skeletal muscle fibres of diet-induced obese mice. Diabetologia. 2021 Mar 12. doi: 10.1007/s00125-021-05418-2
Protective effect of the hydroalcoholic extract from Lampaya medicinalis Phil. (Verbenaceae) on palmitic acid- impaired insulin signaling in 3T3-L1 adipocytes. Obes Res Clin Pract. 2020 Nov-Dec;14(6):573-579. doi: 10.1016/j.orcp.2020.11.001. Epub 2020 Nov 15.
Chronic modafinil administration to preadolescent rats impairs social play behavior and dopaminergic system. Neuropharmacology. 2021 Feb 1;183:108404. doi: 10.1016/j.neuropharm.2020.108404. Epub 2020 Nov 13.
Metformin during Pregnancy: Effects on Offspring Development and Metabolic Function. Front Pharmacol. 2020 Jun 17;11:653. doi: 10.3389/fphar.2020.00653. eCollection 2020.
Prenatal metformin treatment improves ovarian function in offspring of obese rats. Álvarez D, Ceballo K, Olguín S, Martinez-Pinto J, Maliqueo M, Fernandois D, Sotomayor-Zárate R, Cruz G. J Endocrinol. 2018 Dec 1;239(3):325-338. doi: 10.1530/JOE-18-0352.
Neonatal exposure to oestradiol increases dopaminergic transmission in nucleus accumbens and morphine-induced conditioned place preference in adult female rats. Bonansco C, Martínez-Pinto J, Silva RA, Velásquez VB, Martorell A, Selva MV, Espinosa P, Moya PR, Cruz G, Andrés ME, Sotomayor-Zárate R. J Neuroendocrinol. 2018 Jul;30(7):e12574. doi: 10.1111/jne.12574.
Obesity during pregnancy affects sex steroid concentrations depending on fetal gender. Maliqueo M, Cruz G, Espina C, Contreras I, García M, Echiburú B, Crisosto N. Int J Obes (Lond). 2017 Nov;41(11):1636-1645. doi: 10.1038/ijo.2017.159. Epub 2017 Jul 5.
Amphetamine treatment affects the extra-hypothalamic vasopressinergic system in a sex- and nucleus-dependent manner. Ahumada C, Bahamondes C, Cerda CA, Silva RA, Cruz G, Moya PR, Sotomayor-Zárate R, Renard GM. J Neuroendocrinol. 2017 Apr;29(4). doi: 10.1111/jne.12465.
Kisspeptin level in the aging ovary is regulated by the sympathetic nervous system. Fernandois D, Cruz G, Na EK, Lara HE, Paredes AH. J Endocrinol. 2017 Jan;232(1):97-105.
Ovarian function and reproductive senescence in the rat: role of ovarian sympathetic innervation. Cruz G, Fernandois D, Paredes AH. Reproduction. 2017 Feb;153(2):R59-R68. Epub 2016 Oct 31. Review.
Programming of Dopaminergic Neurons by Neonatal Sex Hormone Exposure: Effects on Dopamine Content and Tyrosine Hydroxylase Expression in Adult Male Rats. Espinosa P, Silva RA, Sanguinetti NK, Venegas FC, Riquelme R, González LF, Cruz G, Renard GM, Moya PR, Sotomayor-Zárate R. Neural Plast. 2016;2016:4569785. doi: 10.1155/2016/4569785. Epub 2016 Jan 10.
Increase in endogenous estradiol in the progeny of obese rats is associated with precocious puberty and altered follicular development in adulthood. Ambrosetti V, Guerra M, Ramírez LA, Reyes A, Álvarez D, Olguín S, González-Mañan D, Fernandois D, Sotomayor-Zárate R, Cruz G. Endocrine. 2016 Jul;53(1):258-70. doi: 10.1007/s12020-016-0858-0. Epub 2016 Jan 14.
Kisspeptin is involved in ovarian follicular development during aging in rats. Fernandois D, Na E, Cuevas F, Cruz G, Lara HE, Paredes AH. J Endocrinol. 2016 Mar;228(3):161-70. doi: 10.1530/JOE-15-0429. Epub 2015 Dec 23.
Pharmacological models and approaches for pathophysiological conditions associated with hypoxia and oxidative stress. Farías JG, Herrera EA, Carrasco-Pozo C, Sotomayor-Zárate R, Cruz G, Morales P, Castillo RL. Pharmacol Ther. 2016 Feb;158:1-23. doi: 10.1016/j.pharmthera.2015.11.006. Epub 2015 Nov 23. Review.